Targeted mutagenesis in mouse cells and embryos using an enhanced prime editor

Prime editors, novel genome-editing tools consisting of a CRISPR-Cas9 nickase and an engineered reverse transcriptase, can induce targeted mutagenesis. Nevertheless, much effort is required to optimize and improve the efficiency of prime-editing. Herein, we introduce two strategies to improve the ed...

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Detalles Bibliográficos
Autores principales: Park, Soo-Ji, Jeong, Tae Yeong, Shin, Seung Kyun, Yoon, Da Eun, Lim, Soo-Yeon, Kim, Sol Pin, Choi, Jungmin, Lee, Hyunji, Hong, Jeong-Im, Ahn, Jinhee, Seong, Je Kyung, Kim, Kyoungmi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8173820/
https://www.ncbi.nlm.nih.gov/pubmed/34082781
http://dx.doi.org/10.1186/s13059-021-02389-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8173820/
https://www.ncbi.nlm.nih.gov/pubmed/34082781
http://dx.doi.org/10.1186/s13059-021-02389-w

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