Manganese (II) chloride leads to dopaminergic neurotoxicity by promoting mitophagy through BNIP3-mediated oxidative stress in SH-SY5Y cells

BACKGROUND: Manganese overexposure can induce neurotoxicity, lead to manganism and result in clinical manifestations similar to those of parkinsonism. However, the underlying molecular mechanism is still unclear. This study demonstrated that MnCl(2) induces mitophagy and leads to neurotoxicity by pr...

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Detalles Bibliográficos
Autores principales: Huang, Yanning, Wen, Qiaolin, Huang, Jinfeng, Luo, Man, Xiao, Yousheng, Mo, Ruikang, Wang, Jin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research Letter
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8173824/
https://www.ncbi.nlm.nih.gov/pubmed/34078255
http://dx.doi.org/10.1186/s11658-021-00267-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8173824/
https://www.ncbi.nlm.nih.gov/pubmed/34078255
http://dx.doi.org/10.1186/s11658-021-00267-8

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