Cardiac‐Specific Deletion of Orai3 Leads to Severe Dilated Cardiomyopathy and Heart Failure in Mice

BACKGROUND: Orai3 is a mammalian‐specific member of the Orai family (Orai1‒3) and a component of the store‐operated Ca(2+) entry channels. There is little understanding of the role of Orai channels in cardiomyocytes, and its role in cardiac function remains unexplored. Thus, we developed mice lackin...

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Detalles Bibliográficos
Autores principales: Gammons, Jesse, Trebak, Mohamed, Mancarella, Salvatore
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8174158/
https://www.ncbi.nlm.nih.gov/pubmed/33849280
http://dx.doi.org/10.1161/JAHA.120.019486

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