Cargando…
Novel RyR2 Mutation (G3118R) Is Associated With Autosomal Recessive Ventricular Fibrillation and Sudden Death: Clinical, Functional, and Computational Analysis
BACKGROUND: The cardiac ryanodine receptor type 2 (RyR2) is a large homotetramer, located in the sarcoplasmic reticulum (SR), which releases Ca(2+) from the SR during systole. The molecular mechanism underlying Ca(2+) sensing and gating of the RyR2 channel in health and disease is only partially elu...
Autores principales: | , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8174198/ https://www.ncbi.nlm.nih.gov/pubmed/33686871 http://dx.doi.org/10.1161/JAHA.120.017128 |