Long‐Term Dipeptidyl Peptidase 4 Inhibition Worsens Hypertension and Renal and Cardiac Abnormalities in Obese Spontaneously Hypertensive Heart Failure Rats

BACKGROUND: The long‐term effects of dipeptidyl peptidase 4 (DPP4) inhibitors on blood pressure and cardiovascular and renal health remain controversial. Herein, we investigated the extended (>182 days) effects of DPP4 inhibition in a model of spontaneous hypertension, heart failure, diabetes mel...

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Detalles Bibliográficos
Autores principales: Jackson, Edwin K., Mi, Zaichuan, Gillespie, Delbert G., Cheng, Dongmei, Tofovic, Stevan P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8174220/
https://www.ncbi.nlm.nih.gov/pubmed/33682436
http://dx.doi.org/10.1161/JAHA.120.020088

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8174220/
https://www.ncbi.nlm.nih.gov/pubmed/33682436
http://dx.doi.org/10.1161/JAHA.120.020088

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