Oncohistone mutations enhance chromatin remodeling and alter cell fates

Whole genome sequencing data mining efforts have revealed numerous histone mutations in a wide range of cancer types. These occur in all four core histones in both the tail and globular domains and remain largely uncharacterized. Here we used two high-throughput approaches, a DNA-barcoded mononucleo...

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Detalles Bibliográficos
Autores principales: Bagert, John D., Mitchener, Michelle M., Patriotis, Agata L., Dul, Barbara E., Wojcik, Felix, Nacev, Benjamin A., Feng, Lijuan, Allis, C. David, Muir, Tom W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8174649/
https://www.ncbi.nlm.nih.gov/pubmed/33649601
http://dx.doi.org/10.1038/s41589-021-00738-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8174649/
https://www.ncbi.nlm.nih.gov/pubmed/33649601
http://dx.doi.org/10.1038/s41589-021-00738-1

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