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Oncohistone mutations enhance chromatin remodeling and alter cell fates
Whole genome sequencing data mining efforts have revealed numerous histone mutations in a wide range of cancer types. These occur in all four core histones in both the tail and globular domains and remain largely uncharacterized. Here we used two high-throughput approaches, a DNA-barcoded mononucleo...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8174649/ https://www.ncbi.nlm.nih.gov/pubmed/33649601 http://dx.doi.org/10.1038/s41589-021-00738-1 |