Insights Into Mutations Induced Conformational Changes and Rearrangement of Fe(2+) Ion in pncA Gene of Mycobacterium tuberculosis to Decipher the Mechanism of Resistance to Pyrazinamide

Pyrazinamide (PZA) is the first-line drug commonly used in treating Mycobacterium tuberculosis (Mtb) infections and reduces treatment time by 33%. This prodrug is activated and converted to an active form, Pyrazinoic acid (POA), by Pyrazinamidase (PZase) enzyme. Mtb resistance to PZA is the outcome...

Descripción completa

Detalles Bibliográficos
Autores principales: Nangraj, Asma Sindhoo, Khan, Abbas, Umbreen, Shaheena, Sahar, Sana, Arshad, Maryam, Younas, Saba, Ahmad, Sajjad, Ali, Shahid, Ali, Syed Shujait, Ali, Liaqat, Wei, Dong-Qing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Molecular Biosciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8174790/
https://www.ncbi.nlm.nih.gov/pubmed/34095218
http://dx.doi.org/10.3389/fmolb.2021.633365

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8174790/
https://www.ncbi.nlm.nih.gov/pubmed/34095218
http://dx.doi.org/10.3389/fmolb.2021.633365

Ejemplares similares