C/EBPβ promotes poly(ADP-ribose) polymerase inhibitor resistance by enhancing homologous recombination repair in high-grade serous ovarian cancer

PARP inhibitors (PARPi) are efficacious in treating high-grade serous ovarian cancer (HG-SOC) with homologous recombination (HR) deficiency. However, they exhibit suboptimal efficiency in HR-proficient cancers. Here, we found that the expression of CCAAT/enhancer-binding protein β (C/EBPβ), a transc...

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Detalles Bibliográficos
Autores principales: Tan, Jiahong, Zheng, Xu, Li, Mengchen, Ye, Fei, Song, Chunyan, Xu, Cheng, Zhang, Xiaoxue, Li, Wenqian, Wang, Ya, Zeng, Shaoqing, Li, Huayi, Chen, Gang, Huang, Xiaoyuan, Ma, Ding, Liu, Dan, Gao, Qinglei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8175237/
https://www.ncbi.nlm.nih.gov/pubmed/33966038
http://dx.doi.org/10.1038/s41388-021-01788-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8175237/
https://www.ncbi.nlm.nih.gov/pubmed/33966038
http://dx.doi.org/10.1038/s41388-021-01788-4

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