Translational CNS Steady-State Drug Disposition Model in Rats, Monkeys, and Humans for Quantitative Prediction of Brain-to-Plasma and Cerebrospinal Fluid-to-Plasma Unbound Concentration Ratios

Capturing unbound drug exposure in the brain is crucial to evaluate pharmacological effects for drugs acting on the central nervous system. However, to date, there are no reports of validated prediction models to determine the brain-to-plasma unbound concentration ratio (K(p,uu,brain)) as well as th...

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Detalles Bibliográficos
Autores principales: Sato, Sho, Matsumiya, Kota, Tohyama, Kimio, Kosugi, Yohei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8175309/
https://www.ncbi.nlm.nih.gov/pubmed/34085128
http://dx.doi.org/10.1208/s12248-021-00609-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8175309/
https://www.ncbi.nlm.nih.gov/pubmed/34085128
http://dx.doi.org/10.1208/s12248-021-00609-6

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