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Structural basis of complex formation between mitochondrial anion channel VDAC1 and Hexokinase-II
Complex formation between hexokinase-II (HKII) and the mitochondrial VDAC1 is crucial to cell growth and survival. We hypothesize that HKII first inserts into the outer membrane of mitochondria (OMM) and then interacts with VDAC1 on the cytosolic leaflet of OMM to form a binary complex. To systemati...
Autores principales: | Haloi, Nandan, Wen, Po-Chao, Cheng, Qunli, Yang, Meiying, Natarajan, Gayathri, Camara, Amadou K. S., Kwok, Wai-Meng, Tajkhorshid, Emad |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8175357/ https://www.ncbi.nlm.nih.gov/pubmed/34083717 http://dx.doi.org/10.1038/s42003-021-02205-y |
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