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Acute myeloid leukemia with IDH1 and IDH2 mutations: 2021 treatment algorithm

Acute myeloid leukemia is a genetically heterogeneous hematologic malignancy; approximately 20% of AML harbors a mutation in the isocitrate dehydrogenase (IDH) genes, IDH1 or IDH2. These recurrent mutations in key metabolic enzymes lead to the production of the oncometabolite 2-hydroxyglutarate, whi...

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Detalles Bibliográficos
Autores principales: Issa, Ghayas C., DiNardo, Courtney D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8175383/
https://www.ncbi.nlm.nih.gov/pubmed/34083508
http://dx.doi.org/10.1038/s41408-021-00497-1