Sgpl1 deletion elevates S1P levels, contributing to NPR2 inactivity and p21 expression that block germ cell development

Sphingosine phosphate lyase 1 (SGPL1) is a highly conserved enzyme that irreversibly degrades sphingosine-1-phosphate (S1P). Sgpl1-knockout mice fail to develop germ cells, resulting in infertility. However, the molecular mechanism remains unclear. The results of the present study showed that SGPL1...

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Detalles Bibliográficos
Autores principales: Yuan, Feifei, Wang, Zhijuan, Sun, Yanli, Wei, Hongwei, Cui, Yanying, Wu, Zhanying, Zhang, Chunyu, Xie, Ke-Ping, Wang, Fengchao, Zhang, Meijia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8175456/
https://www.ncbi.nlm.nih.gov/pubmed/34083520
http://dx.doi.org/10.1038/s41419-021-03848-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8175456/
https://www.ncbi.nlm.nih.gov/pubmed/34083520
http://dx.doi.org/10.1038/s41419-021-03848-9

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