Nuclear compartmentalization of TERT mRNA and TUG1 lncRNA is driven by intron retention

The spatial partitioning of the transcriptome in the cell is an important form of gene-expression regulation. Here, we address how intron retention influences the spatio-temporal dynamics of transcripts from two clinically relevant genes: TERT (Telomerase Reverse Transcriptase) pre-mRNA and TUG1 (Ta...

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Detalles Bibliográficos
Autores principales: Dumbović, Gabrijela, Braunschweig, Ulrich, Langner, Heera K., Smallegan, Michael, Biayna, Josep, Hass, Evan P., Jastrzebska, Katarzyna, Blencowe, Benjamin, Cech, Thomas R., Caruthers, Marvin H., Rinn, John L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8175569/
https://www.ncbi.nlm.nih.gov/pubmed/34083519
http://dx.doi.org/10.1038/s41467-021-23221-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8175569/
https://www.ncbi.nlm.nih.gov/pubmed/34083519
http://dx.doi.org/10.1038/s41467-021-23221-w

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