Generation of tetracycline-controllable CYP3A4-expressing Caco-2 cells by the piggyBac transposon system

Caco-2 cells are widely used as an in vitro intestinal epithelial cell model because they can form a monolayer and predict drug absorption with high accuracy. However, Caco-2 cells hardly express cytochrome P450 (CYP), a drug-metabolizing enzyme. It is known that CYP3A4 is the dominant drug-metaboli...

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Detalles Bibliográficos
Autores principales: Ichikawa, Moe, Akamine, Hiroki, Murata, Michika, Ito, Sumito, Takayama, Kazuo, Mizuguchi, Hiroyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8175591/
https://www.ncbi.nlm.nih.gov/pubmed/34083621
http://dx.doi.org/10.1038/s41598-021-91160-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8175591/
https://www.ncbi.nlm.nih.gov/pubmed/34083621
http://dx.doi.org/10.1038/s41598-021-91160-z

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