STAT1 potentiates oxidative stress revealing a targetable vulnerability that increases phenformin efficacy in breast cancer

Bioenergetic perturbations driving neoplastic growth increase the production of reactive oxygen species (ROS), requiring a compensatory increase in ROS scavengers to limit oxidative stress. Intervention strategies that simultaneously induce energetic and oxidative stress therefore have therapeutic p...

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Autores principales: Totten, Stephanie P., Im, Young Kyuen, Cepeda Cañedo, Eduardo, Najyb, Ouafa, Nguyen, Alice, Hébert, Steven, Ahn, Ryuhjin, Lewis, Kyle, Lebeau, Benjamin, La Selva, Rachel, Sabourin, Valérie, Martínez, Constanza, Savage, Paul, Kuasne, Hellen, Avizonis, Daina, Santos Martínez, Nancy, Chabot, Catherine, Aguilar-Mahecha, Adriana, Goulet, Marie-Line, Dankner, Matthew, Witcher, Michael, Petrecca, Kevin, Basik, Mark, Pollak, Michael, Topisirovic, Ivan, Lin, Rongtuan, Siegel, Peter M., Kleinman, Claudia L., Park, Morag, St-Pierre, Julie, Ursini-Siegel, Josie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8175605/
https://www.ncbi.nlm.nih.gov/pubmed/34083537
http://dx.doi.org/10.1038/s41467-021-23396-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8175605/
https://www.ncbi.nlm.nih.gov/pubmed/34083537
http://dx.doi.org/10.1038/s41467-021-23396-2

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