DC-SIGN binding to mannosylated B-cell receptors in follicular lymphoma down-modulates receptor signaling capacity

In follicular lymphoma (FL), surface immunoglobulin (sIg) carries mandatory N-glycosylation sites in the variable regions, inserted during somatic hypermutation. These glycosylation sites are tumor-specific, indicating a critical function in FL. Added glycan unexpectedly terminates at high mannose (...

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Detalles Bibliográficos
Autores principales: Valle-Argos, Beatriz, Chiodin, Giorgia, Bryant, Dean J., Taylor, Joe, Lemm, Elizabeth, Duriez, Patrick J., Rock, Philip J., Strefford, Jonathan C., Forconi, Francesco, Burack, Richard W., Packham, Graham, Stevenson, Freda K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8175722/
https://www.ncbi.nlm.nih.gov/pubmed/34083646
http://dx.doi.org/10.1038/s41598-021-91112-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8175722/
https://www.ncbi.nlm.nih.gov/pubmed/34083646
http://dx.doi.org/10.1038/s41598-021-91112-7

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