Cargando…

BET inhibitor suppresses migration of human hepatocellular carcinoma by inhibiting SMARCA4

Hepatocellular carcinoma (HCC) is one of the most prevalent and poorly responsive cancers worldwide. Bromodomain and extraterminal (BET) inhibitors, such as JQ1 and OTX-015, inhibit BET protein binding to acetylated residues in histones. However, the physiological mechanisms and regulatory processes...

Descripción completa

Detalles Bibliográficos
Autores principales:	Choi, Hae In, An, Ga Yeong, Baek, Mina, Yoo, Eunyoung, Chai, Jin Choul, Lee, Young Seek, Jung, Kyoung Hwa, Chai, Young Gyu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8175750/ https://www.ncbi.nlm.nih.gov/pubmed/34083693 http://dx.doi.org/10.1038/s41598-021-91284-2

Ejemplares similares

The BET inhibitor attenuates the inflammatory response and cell migration in human microglial HMC3 cell line
por: Baek, Mina, et al.
Publicado: (2021)

Comprehensive transcriptome profiling of BET inhibitor-treated HepG2 cells
por: Baek, Mina, et al.
Publicado: (2022)

The bromodomain inhibitor JQ1 up-regulates the long non-coding RNA MALAT1 in cultured human hepatic carcinoma cells
por: Choi, Hae In, et al.
Publicado: (2022)

Targeting of non-coding RNAs encoded by novel MYC enhancers inhibits the proliferation of human hepatic carcinoma cells in vitro
por: Choi, Hae In, et al.
Publicado: (2022)

Analysis of differentially expressed long non-coding RNAs in LPS-induced human HMC3 microglial cells
por: Baek, Mina, et al.
Publicado: (2022)

RNA sequencing reveals distinct mechanisms underlying BET inhibitor JQ1-mediated modulation of the LPS-induced activation of BV-2 microglial cells
por: Jung, Kyoung Hwa, et al.
Publicado: (2015)

Dual transcriptome sequencing reveals resistance of TLR4 ligand-activated bone marrow-derived macrophages to inflammation mediated by the BET inhibitor JQ1
por: Das, Amitabh, et al.
Publicado: (2015)

Transcriptome sequencing of microglial cells stimulated with TLR3 and TLR4 ligands
por: Das, Amitabh, et al.
Publicado: (2015)

Dual RNA Sequencing Reveals the Expression of Unique Transcriptomic Signatures in Lipopolysaccharide-Induced BV-2 Microglial Cells
por: Das, Amitabh, et al.
Publicado: (2015)

RNA sequencing reveals resistance of TLR4 ligand-activated microglial cells to inflammation mediated by the selective jumonji H3K27 demethylase inhibitor
por: Das, Amitabh, et al.
Publicado: (2017)

RNA Sequencing Reveals the Alteration of the Expression of Novel Genes in Ethanol-Treated Embryoid Bodies
por: Mandal, Chanchal, et al.
Publicado: (2016)

GSK-J4-Mediated Transcriptomic Alterations in Differentiating Embryoid Bodies
por: Mandal, Chanchal, et al.
Publicado: (2017)

Transcriptomic Profiling and H3K27me3 Distribution Reveal Both Demethylase-Dependent and Independent Regulation of Developmental Gene Transcription in Cell Differentiation
por: Kang, Sung Chul, et al.
Publicado: (2015)

Transcriptome sequencing reveals that LPS-triggered transcriptional responses in established microglia BV2 cell lines are poorly representative of primary microglia
por: Das, Amitabh, et al.
Publicado: (2016)

Transcriptome sequencing wide functional analysis of human mesenchymal stem cells in response to TLR4 ligand
por: Kim, Sun Hwa, et al.
Publicado: (2016)

Genome-scale DNA methylation pattern profiling of human bone marrow mesenchymal stem cells in long-term culture
por: Choi, Mi Ran, et al.
Publicado: (2012)

Energy Metabolism in Mycobacterium gilvum PYR-GCK: Insights from Transcript Expression Analyses Following Two States of Induction
por: Badejo, Abimbola Comfort, et al.
Publicado: (2014)

TLR3-/4-Priming Differentially Promotes Ca(2+) Signaling and Cytokine Expression and Ca(2+)-Dependently Augments Cytokine Release in hMSCs
por: Park, Kyoung Sun, et al.
Publicado: (2016)

Epigenetic regulation of IFITM1 expression in lipopolysaccharide-stimulated human mesenchymal stromal cells
por: Kim, Sun Hwa, et al.
Publicado: (2020)

Genetic populations of Bacillus anthracis isolates from Korea
por: Jung, Kyoung Hwa, et al.
Publicado: (2012)

Genetic diversity of Korean Bacillus anthracis isolates from soil evaluated with a single nucleotide repeat analysis
por: Kim, Sang Hoon, et al.
Publicado: (2013)

High-Resolution Mapping and Dynamics of the Transcriptome, Transcription Factors, and Transcription Co-Factor Networks in Classically and Alternatively Activated Macrophages
por: Das, Amitabh, et al.
Publicado: (2018)

Analysis of SMARCA4 and SMARCA2 Loss in Lung Sarcomatoid Carcinomas
por: Urer, Halide Nur, et al.
Publicado: (2023)

Case Series of SMARCA4-Deficient Undifferentiated Esophageal Carcinoma
por: Ahmed, Omar T, et al.
Publicado: (2022)

High expression of SMARCA4 or SMARCA2 is frequently associated with an opposite prognosis in cancer
por: Guerrero-Martínez, Jose A., et al.
Publicado: (2018)

Selective PROTAC-mediated degradation of SMARCA2 is efficacious in SMARCA4 mutant cancers
por: Cantley, Jennifer, et al.
Publicado: (2022)

Transcriptome analysis of iBET-151, a BET inhibitor alone and in combination with paclitaxel in gastric cancer cells
por: Kang, Sun Kyoung, et al.
Publicado: (2020)

The Role of NF-κB and H3K27me3 Demethylase, Jmjd3, on the Anthrax Lethal Toxin Tolerance of RAW 264.7 Cells
por: Das, Nando Dulal, et al.
Publicado: (2010)

Changes in Bacillus anthracis CodY regulation under host-specific environmental factor deprived conditions
por: Kim, Se Kye, et al.
Publicado: (2016)

Complex Alternative Splicing of the Smarca2 Gene Suggests the Importance of Smarca2-B Variants
por: Yang, Min, et al.
Publicado: (2011)

In Utero Alcohol Exposure and the Alteration of Histone Marks in the Developing Fetus: An Epigenetic Phenomenon of Maternal Drinking
por: Mandal, Chanchal, et al.
Publicado: (2017)

Gestational Alcohol Exposure Altered DNA Methylation Status in the Developing Fetus
por: Mandal, Chanchal, et al.
Publicado: (2017)

Concomitant loss of SMARCA2 and SMARCA4 expression in small cell carcinoma of the ovary, hypercalcemic type
por: Jelinic, Petar, et al.
Publicado: (2016)

Hyperglycemia-Suppressed SMARCA5 Disrupts Transcriptional Homeostasis to Facilitate Endothelial Dysfunction in Diabetes
por: Wang, Ju, et al.
Publicado: (2023)

Coordinated epigenetic regulation of Engrailed-1 by the chromatin remodelers Smarca1 and Smarca5 mediates cerebellar morphogenesis
por: Alvarez-Saavedra, Matias, et al.
Publicado: (2013)

Regulation of 4-HNE via SMARCA4 Is Associated with Worse Clinical Outcomes in Hepatocellular Carcinoma
por: Watabe, Shiori, et al.
Publicado: (2023)

The Effects of Natural Daylight on Length of Hospital Stay
por: Park, Man Young, et al.
Publicado: (2018)

Effects of the monoamine oxidase inhibitors pargyline and tranylcypromine on cellular proliferation in human prostate cancer cells
por: LEE, HYUNG TAE, et al.
Publicado: (2013)

To Bet or Not to Bet on T-bet As a Therapeutic Target in Emphysema?
por: Wang, Xiaoyun, et al.
Publicado: (2019)

The SMARCA4(R1157W) mutation facilitates chromatin remodeling and confers PRMT1/SMARCA4 inhibitors sensitivity in colorectal cancer
por: Zeng, Xiangwei, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_ick8j8t5oqqabsu1b0aq3vhpjr