Cataract-causing allele in CRYAA (Y118D) proceeds through endoplasmic reticulum stress in mouse model

As small heat shock proteins, α-crystallins function as molecular chaperones and inhibit the misfolding and aggregation of β/γ-crystallins. Genetic mutations of CRYAA are associated with protein aggregation and cataract occurrence. One possible process underlying cataract formation is that endoplasm...

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Detalles Bibliográficos
Autores principales: Jia, Zhe-Kun, Fu, Chen-Xi, Wang, Ai-Ling, Yao, Ke, Chen, Xiang-Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Science Press 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8175955/
https://www.ncbi.nlm.nih.gov/pubmed/33929105
http://dx.doi.org/10.24272/j.issn.2095-8137.2020.354

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8175955/
https://www.ncbi.nlm.nih.gov/pubmed/33929105
http://dx.doi.org/10.24272/j.issn.2095-8137.2020.354

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