A lymphodepleted non‐human primate model for the assessment of acute on‐target and off‐tumor toxicity of human chimeric antigen receptor‐T cells

OBJECTIVES: Chimeric antigen receptor (CAR)‐T cell therapy possesses the potential to cause unexpected on‐target toxicities that may be life‐threatening. Non‐human primates (NHPs) share considerable structural homology and expression profiles of most proteins with humans and are therefore utilised a...

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Detalles Bibliográficos
Autores principales: Yagyu, Shigeki, Mochizuki, Hidemi, Yamashima, Kumiko, Kubo, Hiroshi, Saito, Shoji, Tanaka, Miyuki, Sakamoto, Kengo, Shimoi, Akihito, Nakazawa, Yozo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8175993/
https://www.ncbi.nlm.nih.gov/pubmed/34123382
http://dx.doi.org/10.1002/cti2.1291

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8175993/
https://www.ncbi.nlm.nih.gov/pubmed/34123382
http://dx.doi.org/10.1002/cti2.1291

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