M2-AChR Mediates Rapid Antidepressant Effects of Scopolamine Through Activating the mTORC1-BDNF Signaling Pathway in the Medial Prefrontal Cortex

Background: Scopolamine, a non-selective muscarinic acetylcholine receptor (M1~5-AChR) antagonist, has rapid and robust antidepressant effects in humans and other species. However, which of the five M-AChRs mediates these therapeutic effects has not been fully identified. Several studies implicate M...

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Detalles Bibliográficos
Autores principales: Liu, Shuang, Shi, Dandan, Sun, Zuoli, He, Yi, Yang, Jian, Wang, Gang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Psychiatry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8176437/
https://www.ncbi.nlm.nih.gov/pubmed/34093254
http://dx.doi.org/10.3389/fpsyt.2021.601985

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8176437/
https://www.ncbi.nlm.nih.gov/pubmed/34093254
http://dx.doi.org/10.3389/fpsyt.2021.601985

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