An 8-Hydroxy-Quinoline Derivative Protects Against Lipopolysaccharide-Induced Lethality in Endotoxemia by Inhibiting HMGB1-Mediated Caspase-11 Signaling

Sepsis, an inflammatory syndrome secondary to infection, is the leading cause of in-hospital lethality. It is evidenced that LPS, the major pathological component of the Gram-negative bacteria membrane, predominantly contributes to the pathogenesis of sepsis. Cytoplasmic lipopolysaccharide (LPS) can...

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Detalles Bibliográficos
Autores principales: Wang, Xiangyu, Shi, Jian, Li, Zhaozheng, Li, Ling, Zhang, Rui, Bai, Yang, Li, Junmei, Liang, Fang, Tang, Yiting
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8176522/
https://www.ncbi.nlm.nih.gov/pubmed/34093202
http://dx.doi.org/10.3389/fphar.2021.673818

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8176522/
https://www.ncbi.nlm.nih.gov/pubmed/34093202
http://dx.doi.org/10.3389/fphar.2021.673818

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