Germline nuclear-predominant Pten murine model exhibits impaired social and perseverative behavior, microglial activation, and increased oxytocinergic activity

BACKGROUND: Autism spectrum disorder (ASD) has a strong genetic etiology. Germline mutation in the tumor suppressor gene PTEN is one of the best described monogenic risk cases for ASD. Animal modeling of cell-specific Pten loss or mutation has provided insight into how disruptions to the function of...

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Detalles Bibliográficos
Autores principales: Sarn, Nick, Thacker, Stetson, Lee, Hyunpil, Eng, Charis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8176582/
https://www.ncbi.nlm.nih.gov/pubmed/34088332
http://dx.doi.org/10.1186/s13229-021-00448-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8176582/
https://www.ncbi.nlm.nih.gov/pubmed/34088332
http://dx.doi.org/10.1186/s13229-021-00448-4

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