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AC2P20 selectively kills Mycobacterium tuberculosis at acidic pH by depleting free thiols

Mycobacterium tuberculosis (Mtb) senses and adapts to host immune cues as part of its pathogenesis. One environmental cue sensed by Mtb is the acidic pH of its host niche in the macrophage phagosome. Disrupting the ability of Mtb to sense and adapt to acidic pH has the potential to reduce survival o...

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Detalles Bibliográficos
Autores principales: Dechow, Shelby J., Coulson, Garry B., Wilson, Michael W., Larsen, Scott D., Abramovitch, Robert B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8176622/
https://www.ncbi.nlm.nih.gov/pubmed/34168865
http://dx.doi.org/10.1039/d1ra03181c