Secondary (iso)BAs cooperate with endogenous ligands to activate FXR under physiological and pathological conditions

IsoBAs, stereoisomers of primary and secondary BAs, are found in feces and plasma of human individuals. BA signaling via the nuclear receptor FXR is crucial for regulation of hepatic and intestinal physiology/pathophysiology. Aim: Investigate the ability of BA-stereoisomers to bind and modulate FXR...

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Detalles Bibliográficos
Autores principales: Zaufel, Alex, van de Wiel, Sandra M.W., Yin, Lu, Fauler, Günter, Chien, Daphne, Dong, Xinzhong, Gilmer, John F., Truong, Jennifer K., Dawson, Paul A., van de Graaf, Stan F. J., Fickert, Peter, Moustafa, Tarek
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8177068/
https://www.ncbi.nlm.nih.gov/pubmed/33895309
http://dx.doi.org/10.1016/j.bbadis.2021.166153

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8177068/
https://www.ncbi.nlm.nih.gov/pubmed/33895309
http://dx.doi.org/10.1016/j.bbadis.2021.166153

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