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Secondary (iso)BAs cooperate with endogenous ligands to activate FXR under physiological and pathological conditions
IsoBAs, stereoisomers of primary and secondary BAs, are found in feces and plasma of human individuals. BA signaling via the nuclear receptor FXR is crucial for regulation of hepatic and intestinal physiology/pathophysiology. Aim: Investigate the ability of BA-stereoisomers to bind and modulate FXR...
| Autores principales: | , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8177068/ https://www.ncbi.nlm.nih.gov/pubmed/33895309 http://dx.doi.org/10.1016/j.bbadis.2021.166153 |