RNase L limits host and viral protein synthesis via inhibition of mRNA export

RNase L is widely thought to limit viral protein synthesis by cleaving host rRNA and viral mRNA, resulting in translation arrest and viral mRNA degradation. Here, we show that the mRNAs of dengue virus and influenza A virus largely escape RNase L–mediated mRNA decay, and this permits viral protein p...

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Detalles Bibliográficos
Autores principales: Burke, James M., Gilchrist, Alison R., Sawyer, Sara L., Parker, Roy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8177694/
https://www.ncbi.nlm.nih.gov/pubmed/34088676
http://dx.doi.org/10.1126/sciadv.abh2479

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8177694/
https://www.ncbi.nlm.nih.gov/pubmed/34088676
http://dx.doi.org/10.1126/sciadv.abh2479

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