Structural basis for activation and allosteric modulation of full-length calcium-sensing receptor

Calcium-sensing receptor (CaSR) is a class C G protein–coupled receptor (GPCR) that plays an important role in calcium homeostasis and parathyroid hormone secretion. Here, we present multiple cryo–electron microscopy structures of full-length CaSR in distinct ligand-bound states. Ligands (Ca(2+) and...

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Detalles Bibliográficos
Autores principales: Wen, Tianlei, Wang, Ziyu, Chen, Xiaozhe, Ren, Yue, Lu, Xuhang, Xing, Yangfei, Lu, Jing, Chang, Shenghai, Zhang, Xing, Shen, Yuequan, Yang, Xue
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8177707/
https://www.ncbi.nlm.nih.gov/pubmed/34088669
http://dx.doi.org/10.1126/sciadv.abg1483

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8177707/
https://www.ncbi.nlm.nih.gov/pubmed/34088669
http://dx.doi.org/10.1126/sciadv.abg1483

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