Salmonella-Mediated Therapy Targeting Indoleamine 2, 3-Dioxygenase 1 (IDO) Activates Innate Immunity and Mitigates Colorectal Cancer Growth

Patients with colon cancer remain largely refractory to current immunotherapeutic strategies. This is, in part, due to the overexpression of the immune checkpoint protein indoleamine 2,3-dioxygenase 1 (IDO). IDO is an important enzyme contributing to tumor-mediated immunosuppression and also correla...

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Detalles Bibliográficos
Autores principales: Phan, Thuy, Nguyen, Vu H., D’Alincourt, Marcela S, Manuel, Edwin R., Kaltcheva, Teodora, Tsai, Weimin, Blazar, Bruce R., Diamond, Don J., Melstrom, Laleh G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8177749/
https://www.ncbi.nlm.nih.gov/pubmed/30824815
http://dx.doi.org/10.1038/s41417-019-0089-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8177749/
https://www.ncbi.nlm.nih.gov/pubmed/30824815
http://dx.doi.org/10.1038/s41417-019-0089-7

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