Ppp6c haploinsufficiency accelerates UV‐induced BRAF(V600E)‐initiated melanomagenesis

According to TCGA database, mutations in PPP6C (encoding phosphatase PP6) are found in c. 10% of tumors from melanoma patients, in which they coexist with BRAF and NRAS mutations. To assess PP6 function in melanoma carcinogenesis, we generated mice in which we could specifically induce BRAF(V600E) e...

Descripción completa

Detalles Bibliográficos
Autores principales: Kanazawa, Kosuke, Kishimoto, Kazuhiro, Nomura, Miyuki, Kurosawa, Koreyuki, Kato, Hiroyuki, Inoue, Yui, Miura, Koh, Fukui, Katsuya, Yamashita, Yoji, Sato, Ikuro, Tsuji, Hiroyuki, Watanabe, Toshio, Tanaka, Takuji, Yasuda, Jun, Tanuma, Nobuhiro, Shima, Hiroshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8177767/
https://www.ncbi.nlm.nih.gov/pubmed/33743547
http://dx.doi.org/10.1111/cas.14895

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8177767/
https://www.ncbi.nlm.nih.gov/pubmed/33743547
http://dx.doi.org/10.1111/cas.14895

Ejemplares similares