Novel knock‐in mouse model for the evaluation of the therapeutic efficacy and toxicity of human podoplanin–targeting agents

Podoplanin is a key molecule for enhancing tumor‐induced platelet aggregation. Podoplanin interacts with CLEC‐2 on platelets via PLatelet Aggregation–inducing domains (PLAGs). Among our generated antibodies, those targeting the fourth PLAG domain (PLAG4) strongly suppress podoplanin–CLEC‐2 binding a...

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Detalles Bibliográficos
Autores principales: Ukaji, Takao, Takemoto, Ai, Shibata, Harumi, Kakino, Mamoru, Takagi, Satoshi, Katayama, Ryohei, Fujita, Naoya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8177788/
https://www.ncbi.nlm.nih.gov/pubmed/33735501
http://dx.doi.org/10.1111/cas.14891

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8177788/
https://www.ncbi.nlm.nih.gov/pubmed/33735501
http://dx.doi.org/10.1111/cas.14891

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