A PI polyamide–TPP conjugate targeting a mtDNA mutation induces cell death of cancer cells with the mutation

Mitochondrial DNA (mtDNA) mutations occur frequently in cancer cells, and some of them are often homoplasmic. Targeting such mtDNA mutations could be a new method for killing cancer cells with minimal impact on normal cells. Pyrrole‐imidazole polyamides (PIPs) are cell‐permeable minor groove binders...

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Detalles Bibliográficos
Autores principales: Koshikawa, Nobuko, Yasui, Nanami, Kida, Yuki, Shinozaki, Yoshinao, Tsuji, Kohei, Watanabe, Takayoshi, Takenaga, Keizo, Nagase, Hiroki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8177799/
https://www.ncbi.nlm.nih.gov/pubmed/33811417
http://dx.doi.org/10.1111/cas.14912

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8177799/
https://www.ncbi.nlm.nih.gov/pubmed/33811417
http://dx.doi.org/10.1111/cas.14912

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