Cargando…

A PI polyamide–TPP conjugate targeting a mtDNA mutation induces cell death of cancer cells with the mutation

Mitochondrial DNA (mtDNA) mutations occur frequently in cancer cells, and some of them are often homoplasmic. Targeting such mtDNA mutations could be a new method for killing cancer cells with minimal impact on normal cells. Pyrrole‐imidazole polyamides (PIPs) are cell‐permeable minor groove binders...

Descripción completa

Detalles Bibliográficos
Autores principales:	Koshikawa, Nobuko, Yasui, Nanami, Kida, Yuki, Shinozaki, Yoshinao, Tsuji, Kohei, Watanabe, Takayoshi, Takenaga, Keizo, Nagase, Hiroki
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2021
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8177799/ https://www.ncbi.nlm.nih.gov/pubmed/33811417 http://dx.doi.org/10.1111/cas.14912

Ejemplares similares

Suppression of non‐small‐cell lung cancer A549 tumor growth by an mtDNA mutation‐targeting pyrrole‐imidazole polyamide‐triphenylphosphonium and a senolytic drug
por: Tsuji, Kohei, et al.
Publicado: (2022)

Intercellular transfer of mitochondrial DNA carrying metastasis-enhancing pathogenic mutations from high- to low-metastatic tumor cells and stromal cells via extracellular vesicles
por: Takenaga, Keizo, et al.
Publicado: (2021)

Association of predicted pathogenic mutations in mitochondrial ND genes with distant metastasis in NSCLC and colon cancer
por: Koshikawa, Nobuko, et al.
Publicado: (2017)

Estimating genome-wide off-target effects for pyrrole-imidazole polyamide binding by a pathway-based expression profiling approach
por: Lin, Jason, et al.
Publicado: (2019)

Targeting the mutant PIK3CA gene by DNA‐alkylating pyrrole‐imidazole polyamide in cervical cancer
por: Krishnamurthy, Sakthisri, et al.
Publicado: (2021)

Use of DNA‐alkylating pyrrole‐imidazole polyamides for anti‐cancer drug sensitivity screening in pancreatic ductal adenocarcinoma
por: Tsujimoto, Akiko, et al.
Publicado: (2022)

MCT4 is induced by metastasis-enhancing pathogenic mitochondrial NADH dehydrogenase gene mutations and can be a therapeutic target
por: Takenaga, Keizo, et al.
Publicado: (2021)

Mitochondria: Endosymbiont bacteria DNA sequence as a target against cancer
por: Nagase, Hiroki, et al.
Publicado: (2021)

Identification of Binding Targets of a Pyrrole-Imidazole Polyamide KR12 in the LS180 Colorectal Cancer Genome
por: Lin, Jason, et al.
Publicado: (2016)

Cancer cell-derived interleukin-33 decoy receptor sST2 enhances orthotopic tumor growth in a murine pancreatic cancer model
por: Takenaga, Keizo, et al.
Publicado: (2020)

Obesity reduces the anticancer effect of AdipoRon against orthotopic pancreatic cancer in diet-induced obese mice
por: Takenaga, Keizo, et al.
Publicado: (2021)

Specific mtDNA Mutations in Mouse Carcinoma Cells Suppress Their Tumor Formation via Activation of the Host Innate Immune System
por: Imanishi, Hirotake, et al.
Publicado: (2013)

Role of the mtDNA Mutations and Mitophagy in Inflammaging
por: Dabravolski, Siarhei A., et al.
Publicado: (2022)

Similar patterns of clonally expanded somatic mtDNA mutations in the colon of heterozygous mtDNA mutator mice and ageing humans
por: Baines, Holly L., et al.
Publicado: (2014)

Healthy, mtDNA-mutation free mesoangioblasts from mtDNA patients qualify for autologous therapy
por: van Tienen, Florence, et al.
Publicado: (2019)

Fusion of Wild-Type Mesoangioblasts with Myotubes of mtDNA Mutation Carriers Leads to a Proportional Reduction in mtDNA Mutation Load
por: Zelissen, Ruby, et al.
Publicado: (2023)

Modulation of mtDNA copy number ameliorates the pathological consequences of a heteroplasmic mtDNA mutation in the mouse
por: Filograna, R., et al.
Publicado: (2019)

Absence of mtDNA mutations in leukocytes of CADASIL patients
por: Abu-Amero, Khaled K, et al.
Publicado: (2008)

Possibility of selection against mtDNA mutations in tumors
por: Khaidakov, M, et al.
Publicado: (2005)

Germline and somatic mtDNA mutations in mouse aging
por: Ma, Hong, et al.
Publicado: (2018)

The Complicated Nature of Somatic mtDNA Mutations in Aging
por: Sanchez-Contreras, Monica, et al.
Publicado: (2022)

Targeting anaplastic lymphoma kinase (ALK) gene alterations in neuroblastoma by using alkylating pyrrole-imidazole polyamides
por: Ota, Yoko, et al.
Publicado: (2021)

Mutation patterns of mtDNA: Empirical inferences for the coding region
por: Santos, Cristina, et al.
Publicado: (2008)

An enhanced MITOMAP with a global mtDNA mutational phylogeny
por: Ruiz-Pesini, Eduardo, et al.
Publicado: (2007)

The mtDNA mutator mouse: Dissecting mitochondrial involvement in aging
por: Edgar, Daniel, et al.
Publicado: (2009)

Recurrent Tissue-Specific mtDNA Mutations Are Common in Humans
por: Samuels, David C., et al.
Publicado: (2013)

Somatic mtDNA Mutation Spectra in the Aging Human Putamen
por: Williams, Siôn L., et al.
Publicado: (2013)

Association of human mtDNA mutations with autism in Iranian patients
por: Mousavizadeh, Kazem, et al.
Publicado: (2013)

mtDNA mutations, hearing loss and aminoglycoside treatment in Mexicans
por: G, Meza, et al.
Publicado: (2015)

A method for mutagenesis of mouse mtDNA and a resource of mouse mtDNA mutations for modeling human pathological conditions
por: Fayzulin, Rafik Z., et al.
Publicado: (2015)

Exercise-induced mitochondrial p53 repairs mtDNA mutations in mutator mice
por: Safdar, Adeel, et al.
Publicado: (2016)

Do mtDNA Mutations Participate in the Pathogenesis of Sporadic Parkinson’s Disease?
por: Kirches, E.
Publicado: (2009)

Correction: Somatic mtDNA Mutation Spectra in the Aging Human Putamen
por: Williams, Siôn L., et al.
Publicado: (2013)

DNA methyltransferase 1 mutations and mitochondrial pathology: is mtDNA methylated?
por: Maresca, Alessandra, et al.
Publicado: (2015)

MtDNA analysis reveals enriched pathogenic mutations in Tibetan highlanders
por: Kang, Longli, et al.
Publicado: (2016)

Mitochondrial diseases caused by mtDNA mutations: a mini-review
por: Ryzhkova, Anastasia I, et al.
Publicado: (2018)

Mitochondrial Genome (mtDNA) Mutations that Generate Reactive Oxygen Species
por: Hahn, Anne, et al.
Publicado: (2019)

Novel mutations in DNA2 associated with myopathy and mtDNA instability
por: Ronchi, Dario, et al.
Publicado: (2019)

MtDNA mutations and aging—not a closed case after all?
por: Wolf, Alexander M.
Publicado: (2021)

The spectrum of mitochondrial DNA (mtDNA) mutations in pediatric CNS tumors
por: Kaneva, Kristiyana, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_n40qhtugujmhit7sgeuktusq73