Cargando…

Cytoplasmic Mislocalization of RNA Polymerase II Subunit RPB1 in Alzheimer Disease Is Linked to Pathologic Tau

Abnormal protein accumulation and mislocalization is a general hallmark of Alzheimer disease. Recent data suggest nucleocytoplasmic transport may be compromised by tau in Alzheimer disease. In this context, we have examined the RNA polymerase II subunit RPB1, which is the catalytic subunit that play...

Descripción completa

Detalles Bibliográficos
Autores principales:	Dickson, John R, Yoon, Hyejin, Frosch, Matthew P, Hyman, Bradley T
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2021
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8177848/ https://www.ncbi.nlm.nih.gov/pubmed/33990839 http://dx.doi.org/10.1093/jnen/nlab040

Ejemplares similares

Crystal structure and RNA binding of the Rpb4/Rpb7 subunits of human RNA polymerase II
por: Meka, Hedije, et al.
Publicado: (2005)

Predictive Potential of RNA Polymerase B (II) Subunit 1 (RPB1) Cytoplasmic Aggregation for Neoadjuvant Chemotherapy Failure
por: Nagy-Mikó, Bence, et al.
Publicado: (2023)

The archaeal RNA polymerase subunit P and the eukaryotic polymerase subunit Rpb12 are interchangeable in vivo and in vitro
por: Reich, Christoph, et al.
Publicado: (2009)

The Rpb7p subunit of yeast RNA polymerase II plays roles in the two major cytoplasmic mRNA decay mechanisms
por: Lotan, Rona, et al.
Publicado: (2007)

The RNA polymerase II subunit Rpb9 activates ATG1 transcription and autophagy
por: Huang, Ting, et al.
Publicado: (2022)

Antibodies to the DNA-directed RNA polymerase II subunit RPB1 occur with highest frequency in centenarians
por: Han, Jungwon, et al.
Publicado: (2016)

Functional organization of the Rpb5 subunit shared by the three yeast RNA polymerases
por: Zaros, Cécile, et al.
Publicado: (2007)

Distinct regions of RPB11 are required for heterodimerization with RPB3 in human and yeast RNA polymerase II
por: Benga, Wagane J., et al.
Publicado: (2005)

Improving Saccharomyces cerevisiae ethanol production and tolerance via RNA polymerase II subunit Rpb7
por: Qiu, Zilong, et al.
Publicado: (2017)

RNA polymerase II plays an active role in the formation of gene loops through the Rpb4 subunit
por: Allepuz-Fuster, Paula, et al.
Publicado: (2019)

Orthologs of the small RPB8 subunit of the eukaryotic RNA polymerases are conserved in hyperthermophilic Crenarchaeota and "Korarchaeota"
por: Koonin, Eugene V, et al.
Publicado: (2007)

Three human RNA polymerases interact with TFIIH via a common RPB6 subunit
por: Okuda, Masahiko, et al.
Publicado: (2021)

The fission yeast Rpb4 subunit of RNA polymerase II plays a specialized role in cell separation
por: Sharma, Nimisha, et al.
Publicado: (2006)

Cerebrovascular Senescence Is Associated With Tau Pathology in Alzheimer's Disease
por: Bryant, Annie G., et al.
Publicado: (2020)

The RNA polymerase II subunit RPB‐9 recruits the integrator complex to terminate Caenorhabditis elegans piRNA transcription
por: Berkyurek, Ahmet C, et al.
Publicado: (2021)

Inhibition of CK2 mitigates Alzheimer’s tau pathology by preventing NR2B synaptic mislocalization
por: Marshall, Courtney A., et al.
Publicado: (2022)

Rpb4/7 facilitates RNA polymerase II CTD dephosphorylation
por: Allepuz-Fuster, Paula, et al.
Publicado: (2014)

Synaptic Tau Seeding Precedes Tau Pathology in Human Alzheimer's Disease Brain
por: DeVos, Sarah L., et al.
Publicado: (2018)

Rpb5, a subunit shared by eukaryotic RNA polymerases, cooperates with prefoldin-like Bud27/URI
por: Martínez-Fernández, Verónica, et al.
Publicado: (2018)

Dissociation of Rpb4 from RNA polymerase II is important for yeast functionality
por: Duek, Lea, et al.
Publicado: (2018)

The Human Isoform of RNA Polymerase II Subunit hRPB11bα Specifically Interacts with Transcription Factor ATF4
por: Proshkin, Sergey A., et al.
Publicado: (2019)

Kinetics of tau aggregation reveals patient-specific tau characteristics among Alzheimer’s cases
por: Kamath, Tarun V, et al.
Publicado: (2021)

Amino Acid Substitutions in the Caenorhabditis elegans RNA Polymerase II Large Subunit AMA-1/RPB-1 that Result in α-Amanitin Resistance and/or Reduced Function
por: Bowman, Elizabeth Anne, et al.
Publicado: (2011)

Promotion of cytoplasmic mislocalization of p27 by Helicobacter pylori in gastric cancer
por: Wen, Sicheng, et al.
Publicado: (2011)

Activation of a Chimeric Rpb5/RpoH Subunit Using Library Selection
por: Sommer, Bettina, et al.
Publicado: (2014)

Propagation of tau pathology in Alzheimer’s disease: identification of novel therapeutic targets
por: Pooler, Amy M, et al.
Publicado: (2013)

Recruitment into stress granules prevents irreversible aggregation of FUS protein mislocalized to the cytoplasm
por: Shelkovnikova, Tatyana A, et al.
Publicado: (2013)

The Prefoldin Bud27 Mediates the Assembly of the Eukaryotic RNA Polymerases in an Rpb5-Dependent Manner
por: Mirón-García, María Carmen, et al.
Publicado: (2013)

The Influenza Virus RNA-Polymerase and the Host RNA-Polymerase II: RPB4 Is Targeted by a PB2 Domain That Is Involved in Viral Transcription
por: Morel, Jessica, et al.
Publicado: (2022)

Different tau species lead to heterogeneous tau pathology propagation and misfolding
por: Dujardin, Simon, et al.
Publicado: (2018)

Importin-Mediated Pathological Tau Nuclear Translocation Causes Disruption of the Nuclear Lamina, TDP-43 Mislocalization and Cell Death
por: Candia, Robert F., et al.
Publicado: (2022)

Non-human primate model of amyotrophic lateral sclerosis with cytoplasmic mislocalization of TDP-43
por: Uchida, Azusa, et al.
Publicado: (2012)

Frequent and symmetric deposition of misfolded tau oligomers within presynaptic and postsynaptic terminals in Alzheimer’s disease
por: Tai, Hwan-Ching, et al.
Publicado: (2014)

Acetylated tau destabilizes the cytoskeleton in the axon initial segment and is mislocalized to the somatodendritic compartment
por: Sohn, Peter Dongmin, et al.
Publicado: (2016)

The expression of Rpb10, a small subunit common to RNA polymerases, is modulated by the R3H domain-containing Rbs1 protein and the Upf1 helicase
por: Cieśla, Małgorzata, et al.
Publicado: (2020)

Live-cell analysis of endogenous GFP-RPB1 uncovers rapid turnover of initiating and promoter-paused RNA Polymerase II
por: Steurer, Barbara, et al.
Publicado: (2018)

The interaction between the Spt6-tSH2 domain and Rpb1 affects multiple functions of RNA Polymerase II
por: Connell, Zaily, et al.
Publicado: (2021)

Mislocalization of protein kinase A drives pathology in Cushing’s syndrome
por: Omar, Mitchell H., et al.
Publicado: (2022)

Point mutations in the Rpb9-homologous domain of Rpc11 that impair transcription termination by RNA polymerase III
por: Iben, James R., et al.
Publicado: (2011)

Molecular mechanisms of RNA polymerase—the F/E (RPB4/7) complex is required for high processivity in vitro
por: Hirtreiter, Angela, et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_6gnkc82j7qha1km3na6vk2c8t7