Hypoxia Induced by Cobalt Chloride Triggers Autophagic Apoptosis of Human and Mouse Drug-Resistant Glioblastoma Cells through Targeting the PI3K-AKT-mTOR Signaling Pathway

Glioblastoma multiforme (GBM) is the most aggressive brain tumor. Drug resistance mainly drives GBM patients to poor prognoses because drug-resistant glioblastoma cells highly defend against apoptotic insults. This study was designed to evaluate the effects of cobalt chloride (CoCl(2)) on hypoxic st...

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Detalles Bibliográficos
Autores principales: Lee, Yuan-Wen, Cherng, Yih-Giun, Yang, Shun-Tai, Liu, Shing-Hwa, Chen, Ta-Liang, Chen, Ruei-Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8177987/
https://www.ncbi.nlm.nih.gov/pubmed/34136065
http://dx.doi.org/10.1155/2021/5558618

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8177987/
https://www.ncbi.nlm.nih.gov/pubmed/34136065
http://dx.doi.org/10.1155/2021/5558618

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