Cargando…

Hypoxia Induced by Cobalt Chloride Triggers Autophagic Apoptosis of Human and Mouse Drug-Resistant Glioblastoma Cells through Targeting the PI3K-AKT-mTOR Signaling Pathway

Glioblastoma multiforme (GBM) is the most aggressive brain tumor. Drug resistance mainly drives GBM patients to poor prognoses because drug-resistant glioblastoma cells highly defend against apoptotic insults. This study was designed to evaluate the effects of cobalt chloride (CoCl(2)) on hypoxic st...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lee, Yuan-Wen, Cherng, Yih-Giun, Yang, Shun-Tai, Liu, Shing-Hwa, Chen, Ta-Liang, Chen, Ruei-Ming
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8177987/ https://www.ncbi.nlm.nih.gov/pubmed/34136065 http://dx.doi.org/10.1155/2021/5558618

Ejemplares similares

Rapamycin treatment increases hippocampal cell viability in an mTOR-independent manner during exposure to hypoxia mimetic, cobalt chloride
por: Zimmerman, Mary A., et al.
Publicado: (2018)

Crocin induces autophagic apoptosis in hepatocellular carcinoma by inhibiting Akt/mTOR activity
por: Yao, Chong, et al.
Publicado: (2018)

Antrodia cinnamomea induces autophagic cell death via the CHOP/TRB3/Akt/mTOR pathway in colorectal cancer cells
por: Tsai, Dai-Hua, et al.
Publicado: (2018)

Moxidectin induces Cytostatic Autophagic Cell Death of Glioma Cells through inhibiting the AKT/mTOR Signalling Pathway
por: Liu, Jingjing, et al.
Publicado: (2020)

PI3K/Akt/mTOR signaling pathway and targeted therapy for glioblastoma
por: Li, Xiaoman, et al.
Publicado: (2016)

Mouse embryonic palatal mesenchymal cells maintain stemness through the PTEN-Akt-mTOR autophagic pathway
por: Shi, Lungang, et al.
Publicado: (2019)

Moxidectin induces Cytostatic Autophagic Cell Death of Glioma Cells through inhibiting the AKT/mTOR Signalling Pathway: Erratum
por: Liu, Jingjing, et al.
Publicado: (2023)

Oncogenic Ras is downregulated by ARHI and induces autophagy by Ras/AKT/mTOR pathway in glioblastoma
por: Zhong, Chen, et al.
Publicado: (2019)

Cobalt chloride-stimulated hypoxia promotes the proliferation of cholesteatoma keratinocytes via the PI3K/Akt signaling pathway
por: Zhang, Chen, et al.
Publicado: (2021)

Arctigenin Inhibits Glioblastoma Proliferation through the AKT/mTOR Pathway and Induces Autophagy
por: Jiang, Yong'an, et al.
Publicado: (2020)

Polyphyllin I Promotes Autophagic Cell Death and Apoptosis of Colon Cancer Cells via the ROS-Inhibited AKT/mTOR Pathway
por: Luo, Qihui, et al.
Publicado: (2022)

The Paradox of Akt-mTOR Interactions
por: Vadlakonda, Lakshmipathi, et al.
Publicado: (2013)

YAP accelerates vascular senescence via blocking autophagic flux and activating mTOR
por: Pan, Xianmei, et al.
Publicado: (2020)

Regulation of Osteoclast Growth and Fusion by mTOR/raptor and mTOR/rictor/Akt
por: Tiedemann, Kerstin, et al.
Publicado: (2017)

Autophagy activation promotes bevacizumab resistance in glioblastoma by suppressing Akt/mTOR signaling pathway
por: Huang, He, et al.
Publicado: (2018)

Wnt and PI3K/Akt/mTOR Survival Pathways as Therapeutic Targets in Glioblastoma
por: Barzegar Behrooz, Amir, et al.
Publicado: (2022)

Ubiquilins Regulate Autophagic Flux through mTOR Signaling and Lysosomal Acidification
por: Şentürk, Mümine, et al.
Publicado: (2019)

EGFR and mTOR as therapeutic targets in glioblastoma
por: Ronellenfitsch, Michael W., et al.
Publicado: (2019)

Sinomenine ester derivative inhibits glioblastoma by inducing mitochondria-dependent apoptosis and autophagy by PI3K/AKT/mTOR and AMPK/mTOR pathway
por: Zheng, Xiangjin, et al.
Publicado: (2021)

Nitidine Chloride Triggers Autophagy and Apoptosis of Ovarian Cancer Cells through Akt/mTOR Signaling Pathway
por: Lian, Chaoqun, et al.
Publicado: (2023)

Targeting AKT/mTOR and Bcl-2 for Autophagic and Apoptosis Cell Death in Lung Cancer: Novel Activity of a Polyphenol Compound
por: Tungsukruthai, Sucharat, et al.
Publicado: (2021)

Selaginella tamariscina Inhibits Glutamate-Induced Autophagic Cell Death by Activating the PI3K/AKT/mTOR Signaling Pathways
por: Jeong, Yun Hee, et al.
Publicado: (2022)

Methylpiperidinopyrazole Attenuates Estrogen-Induced Mitochondrial Energy Production and Subsequent Osteoblast Maturation via an Estrogen Receptor Alpha-Dependent Mechanism
por: Yeh, Poh-Shiow, et al.
Publicado: (2020)

Carnosine inhibits glioblastoma growth independent from PI3K/Akt/mTOR signaling
por: Oppermann, Henry, et al.
Publicado: (2019)

AMPK–mTOR Signaling and Cellular Adaptations in Hypoxia
por: Chun, Yoomi, et al.
Publicado: (2021)

The Akt/mTOR pathway in cancer stem/progenitor cells is a potential therapeutic target for glioblastoma and neuroblastoma
por: Bahmad, Hisham F., et al.
Publicado: (2018)

Knockdown of CLN5 inhibits the tumorigenic properties of glioblastoma cells via the Akt/mTOR signaling pathway
por: Xing, Jiexia, et al.
Publicado: (2021)

Akt and mTOR in B Cell Activation and Differentiation
por: Limon, Jose J., et al.
Publicado: (2012)

Akt and mTOR mediate programmed necrosis in neurons
por: Liu, Q, et al.
Publicado: (2014)

Downregulation of protein kinase CK2 induces autophagic cell death through modulation of the mTOR and MAPK signaling pathways in human glioblastoma cells
por: OLSEN, BIRGITTE B., et al.
Publicado: (2012)

Acupuncture promotes mTOR-independent autophagic clearance of aggregation-prone proteins in mouse brain
por: Tian, Tian, et al.
Publicado: (2016)

Plasma-activated medium promotes autophagic cell death along with alteration of the mTOR pathway
por: Yoshikawa, Nobuhisa, et al.
Publicado: (2020)

Larotrectinib induces autophagic cell death through AMPK/mTOR signalling in colon cancer
por: Kong, Wencheng, et al.
Publicado: (2022)

Samsoeum, a traditional herbal medicine, elicits apoptotic and autophagic cell death by inhibiting Akt/mTOR and activating the JNK pathway in cancer cells
por: Kim, Aeyung, et al.
Publicado: (2013)

Oleanolic acid induced autophagic cell death in hepatocellular carcinoma cells via PI3K/Akt/mTOR and ROS-dependent pathway
por: Shi, Yang, et al.
Publicado: (2016)

Nerve growth factor-induced Akt/mTOR activation protects the ischemic heart via restoring autophagic flux and attenuating ubiquitinated protein accumulation
por: Wang, Zhou-Guang, et al.
Publicado: (2016)

CXCR4 blockade sensitizes osteosarcoma to doxorubicin by inducing autophagic cell death via PI3K-Akt-mTOR pathway inhibition
por: Liao, Yu-Xin, et al.
Publicado: (2021)

Salvianolic acid B improves autophagic dysfunction and decreases the apoptosis of cholesterol crystal-induced macrophages via inhibiting the Akt/mTOR signaling pathway
por: Sun, Mengqi, et al.
Publicado: (2021)

Modified 5-aminolevulinic acid photodynamic therapy suppresses cutaneous squamous cell carcinoma through blocking Akt/mTOR-mediated autophagic flux
por: Zeng, Qingyu, et al.
Publicado: (2023)

Jagged2 progressively increased expression from Stage I to III of Bladder Cancer and Melatonin-mediated downregulation of Notch/Jagged2 suppresses the Bladder Tumorigenesis via inhibiting PI3K/AKT/mTOR/MMPs signaling
por: Chen, Yen-Ta, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_gjvntoej681aasqj69agim3fdo