Cardiac‐specific overexpression of miR‐122 induces mitochondria‐dependent cardiomyocyte apoptosis and promotes heart failure by inhibiting Hand2

MicroRNA‐122 (miR‐122) is one of several microRNAs elevated in heart failure patients. To investigate the potential role and mechanism of miR‐122 in heart failure, we constructed a transgenic mouse overexpressing miR‐122 in the heart. This mouse exhibited cardiac dysfunction (as assessed by transtho...

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Detalles Bibliográficos
Autores principales: Shi, Yajuan, Zhang, Zhi, Yin, Qiqi, Fu, Chen, Barszczyk, Andrew, Zhang, Xiaofu, Wang, Jiabing, Yang, Deye
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8178264/
https://www.ncbi.nlm.nih.gov/pubmed/33942477
http://dx.doi.org/10.1111/jcmm.16544

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8178264/
https://www.ncbi.nlm.nih.gov/pubmed/33942477
http://dx.doi.org/10.1111/jcmm.16544

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