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The monoamine stabilizer OSU6162 has anxiolytic-like properties and reduces voluntary alcohol intake in a genetic rat model of depression
Alcohol use disorders (AUD) often co-occur with anxiety and depressive disorders, and anxiety often drives relapse during alcohol abstinence. Optimal AUD pharmacotherapies may thus need to target both excessive alcohol intake and elevated anxiety. (−)-OSU6162 (OSU) is a monoamine stabilizer that att...
Autores principales: | Melas, Philippe A., Wirf, Malin, André, Helder, Jayaram-Lindström, Nitya, Mathé, Aleksander A., Steensland, Pia |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8178366/ https://www.ncbi.nlm.nih.gov/pubmed/34088937 http://dx.doi.org/10.1038/s41598-021-91215-1 |
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