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Systemic delivery of antagomirs during blood-brain barrier disruption is disease-modifying in experimental epilepsy
Oligonucleotide therapies offer precision treatments for a variety of neurological diseases, including epilepsy, but their deployment is hampered by the blood-brain barrier (BBB). Previous studies showed that intracerebroventricular injection of an antisense oligonucleotide (antagomir) targeting mic...
Autores principales: | , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society of Gene & Cell Therapy
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8178478/ https://www.ncbi.nlm.nih.gov/pubmed/33609732 http://dx.doi.org/10.1016/j.ymthe.2021.02.021 |