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CDK5 positively regulates Notch1 signaling in pancreatic cancer cells by phosphorylation

The marked overexpression of cyclin‐dependent kinase 5 (CDK5) or Notch1 receptor, which plays critical roles in pancreatic ductal adenocarcinoma (PDAC) development, has been detected in numerous PDAC cell lines and tissues. Although, a previous study has demonstrated that CDK5 inhibition disrupts No...

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Detalles Bibliográficos
Autores principales: Chu, Qiaoyun, Wang, Liyong, Zhang, Jie, Wang, Wei, Wang, Youxin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8178504/
https://www.ncbi.nlm.nih.gov/pubmed/33960694
http://dx.doi.org/10.1002/cam4.3916