Design strategy of antidote sequence for bivalent aptamer: Rapid neutralization of high‐anticoagulant thrombin‐binding bivalent DNA aptamer‐linked M08 with HD22

BACKGROUND: Bivalent thrombin‐binding aptamers (TBAs) have great potential for the treatment of thrombosis because they exhibit high anticoagulant activity, and their complementary single‐stranded DNA (ssDNA) sequences work as an antidote. However, a design strategy for antidote sequences against bi...

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Detalles Bibliográficos
Autores principales: Yoshitomi, Toru, Wakui, Koji, Miyakawa, Masato, Yoshimoto, Keitaro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Brief Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8178692/
https://www.ncbi.nlm.nih.gov/pubmed/34136744
http://dx.doi.org/10.1002/rth2.12503

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8178692/
https://www.ncbi.nlm.nih.gov/pubmed/34136744
http://dx.doi.org/10.1002/rth2.12503

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