Probing conformational hotspots for the recognition and intervention of protein complexes by lysine reactivity profiling

Probing the conformational and functional hotspot sites within aqueous native protein complexes is still a challenging task. Herein, a mass spectrometry (MS)-based two-step isotope labeling-lysine reactivity profiling (TILLRP) strategy is developed to quantify the reactivities of lysine residues and...

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Detalles Bibliográficos
Autores principales: Liu, Zheyi, Zhang, Wenxiang, Sun, Binwen, Ma, Yaolu, He, Min, Pan, Yuanjiang, Wang, Fangjun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8179027/
https://www.ncbi.nlm.nih.gov/pubmed/34163908
http://dx.doi.org/10.1039/d0sc05330a

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8179027/
https://www.ncbi.nlm.nih.gov/pubmed/34163908
http://dx.doi.org/10.1039/d0sc05330a

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