Small molecules targeting the NEDD8·NAE protein–protein interaction

Ubiquitination is a major controller of protein homeostasis in cells. Some ubiquitination pathways are modulated by a NEDDylation cascade, that also features E1 – 3 enzymes. The E1 enzyme in the NEDDylation cascade involves a protein–protein interaction (PPI) between NEDD8 (similar to ubiquitin) and...

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Detalles Bibliográficos
Autores principales: Lin, Chen-Ming, Jiang, Zhengyang, Gao, Zhe, Arancillo, Maritess, Burgess, Kevin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8179036/
https://www.ncbi.nlm.nih.gov/pubmed/34163916
http://dx.doi.org/10.1039/d0sc00958j

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8179036/
https://www.ncbi.nlm.nih.gov/pubmed/34163916
http://dx.doi.org/10.1039/d0sc00958j

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