Pyridylic anions are soft nucleophiles in the palladium-catalyzed C(sp(3))–H allylation of 4-alkylpyridines

We report a mild palladium-catalyzed method for the selective allylation of 4-alkylpyridines in which highly basic pyridylic anions behave as soft nucleophiles. This method exploits alkylidene dihydropyridines, which are semi-stable intermediates readily formed using a ‘soft-enolization’ approach, i...

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Detalles Bibliográficos
Autores principales: Wasfy, Nour, Rasheed, Faizan, Robidas, Raphaël, Hunter, Isabelle, Shi, Jiaqi, Doan, Brian, Legault, Claude Y., Fishlock, Dan, Orellana, Arturo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8179045/
https://www.ncbi.nlm.nih.gov/pubmed/34163914
http://dx.doi.org/10.1039/d0sc03304a

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8179045/
https://www.ncbi.nlm.nih.gov/pubmed/34163914
http://dx.doi.org/10.1039/d0sc03304a

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