Synthesis of 2-oxoglutarate derivatives and their evaluation as cosubstrates and inhibitors of human aspartate/asparagine-β-hydroxylase

2-Oxoglutarate (2OG) is involved in biological processes including oxidations catalyzed by 2OG oxygenases for which it is a cosubstrate. Eukaryotic 2OG oxygenases have roles in collagen biosynthesis, lipid metabolism, DNA/RNA modification, transcriptional regulation, and the hypoxic response. Aspart...

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Detalles Bibliográficos
Autores principales: Brewitz, Lennart, Nakashima, Yu, Schofield, Christopher J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8179049/
https://www.ncbi.nlm.nih.gov/pubmed/34163896
http://dx.doi.org/10.1039/d0sc04301j

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8179049/
https://www.ncbi.nlm.nih.gov/pubmed/34163896
http://dx.doi.org/10.1039/d0sc04301j

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