A pyrone remodeling strategy to access diverse heterocycles: application to the synthesis of fascaplysin natural products

The synthesis of diverse N-fused heterocycles, including the pyrido[1,2-a]indole scaffold, using an efficient pyrone remodeling strategy is described. The pyrido[1,2-a]indole core was demonstrated to be a versatile scaffold that can be site-selectively functionalized. The utility of this novel annul...

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Detalles Bibliográficos
Autores principales: Palani, Vignesh, Perea, Melecio A., Gardner, Kristen E., Sarpong, Richmond
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8179101/
https://www.ncbi.nlm.nih.gov/pubmed/34163915
http://dx.doi.org/10.1039/d0sc06317g
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author Palani, Vignesh
Perea, Melecio A.
Gardner, Kristen E.
Sarpong, Richmond
author_facet Palani, Vignesh
Perea, Melecio A.
Gardner, Kristen E.
Sarpong, Richmond
author_sort Palani, Vignesh
collection PubMed
description The synthesis of diverse N-fused heterocycles, including the pyrido[1,2-a]indole scaffold, using an efficient pyrone remodeling strategy is described. The pyrido[1,2-a]indole core was demonstrated to be a versatile scaffold that can be site-selectively functionalized. The utility of this novel annulation strategy was showcased in a concise formal synthesis of three fascaplysin congeners.
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spelling pubmed-81791012021-06-22 A pyrone remodeling strategy to access diverse heterocycles: application to the synthesis of fascaplysin natural products Palani, Vignesh Perea, Melecio A. Gardner, Kristen E. Sarpong, Richmond Chem Sci Chemistry The synthesis of diverse N-fused heterocycles, including the pyrido[1,2-a]indole scaffold, using an efficient pyrone remodeling strategy is described. The pyrido[1,2-a]indole core was demonstrated to be a versatile scaffold that can be site-selectively functionalized. The utility of this novel annulation strategy was showcased in a concise formal synthesis of three fascaplysin congeners. The Royal Society of Chemistry 2020-11-27 /pmc/articles/PMC8179101/ /pubmed/34163915 http://dx.doi.org/10.1039/d0sc06317g Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Palani, Vignesh
Perea, Melecio A.
Gardner, Kristen E.
Sarpong, Richmond
A pyrone remodeling strategy to access diverse heterocycles: application to the synthesis of fascaplysin natural products
title A pyrone remodeling strategy to access diverse heterocycles: application to the synthesis of fascaplysin natural products
title_full A pyrone remodeling strategy to access diverse heterocycles: application to the synthesis of fascaplysin natural products
title_fullStr A pyrone remodeling strategy to access diverse heterocycles: application to the synthesis of fascaplysin natural products
title_full_unstemmed A pyrone remodeling strategy to access diverse heterocycles: application to the synthesis of fascaplysin natural products
title_short A pyrone remodeling strategy to access diverse heterocycles: application to the synthesis of fascaplysin natural products
title_sort pyrone remodeling strategy to access diverse heterocycles: application to the synthesis of fascaplysin natural products
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8179101/
https://www.ncbi.nlm.nih.gov/pubmed/34163915
http://dx.doi.org/10.1039/d0sc06317g
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