Markov state models and NMR uncover an overlooked allosteric loop in p53

The tumor suppressor p53 is the most frequently mutated gene in human cancer, and thus reactivation of mutated p53 is a promising avenue for cancer therapy. Analysis of wildtype p53 and the Y220C cancer mutant long-timescale molecular dynamics simulations with Markov state models and validation by N...

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Detalles Bibliográficos
Autores principales: Barros, Emilia P., Demir, Özlem, Soto, Jenaro, Cocco, Melanie J., Amaro, Rommie E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8179107/
https://www.ncbi.nlm.nih.gov/pubmed/34163952
http://dx.doi.org/10.1039/d0sc05053a

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8179107/
https://www.ncbi.nlm.nih.gov/pubmed/34163952
http://dx.doi.org/10.1039/d0sc05053a

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