Enhancing glycan stability via site-selective fluorination: modulating substrate orientation by molecular design

Single site OH → F substitution at the termini of maltotetraose leads to significantly improved hydrolytic stability towards α-amylase and α-glucosidase relative to the natural compound. To explore the effect of molecular editing, selectively modified oligosaccharides were prepared via a convergent...

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Detalles Bibliográficos
Autores principales: Axer, Alexander, Jumde, Ravindra P., Adam, Sebastian, Faust, Andreas, Schäfers, Michael, Fobker, Manfred, Koehnke, Jesko, Hirsch, Anna K. H., Gilmour, Ryan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8179167/
https://www.ncbi.nlm.nih.gov/pubmed/34163891
http://dx.doi.org/10.1039/d0sc04297h

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8179167/
https://www.ncbi.nlm.nih.gov/pubmed/34163891
http://dx.doi.org/10.1039/d0sc04297h

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