Dynamic residue interaction network analysis of the oseltamivir binding site of N1 neuraminidase and its H274Y mutation site conferring drug resistance in influenza A virus

BACKGROUND: Oseltamivir (OTV)-resistant influenza virus exhibits His-to-Tyr mutation at residue 274 (H274Y) in N1 neuraminidase (NA). However, the molecular mechanisms by which the H274Y mutation in NA reduces its binding affinity to OTV have not been fully elucidated. METHODS: In this study, we use...

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Detalles Bibliográficos
Autores principales: Yadav, Mohini, Igarashi, Manabu, Yamamoto, Norifumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: PeerJ Inc. 2021
Materias:
Biophysics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8179223/
https://www.ncbi.nlm.nih.gov/pubmed/34141489
http://dx.doi.org/10.7717/peerj.11552

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8179223/
https://www.ncbi.nlm.nih.gov/pubmed/34141489
http://dx.doi.org/10.7717/peerj.11552

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