Identification of β-strand mediated protein–protein interaction inhibitors using ligand-directed fragment ligation

β-Strand mediated protein–protein interactions (PPIs) represent underexploited targets for chemical probe development despite representing a significant proportion of known and therapeutically relevant PPI targets. β-Strand mimicry is challenging given that both amino acid side-chains and backbone h...

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Detalles Bibliográficos
Autores principales: Hegedüs, Zsófia, Hóbor, Fruzsina, Shoemark, Deborah K., Celis, Sergio, Lian, Lu-Yun, Trinh, Chi H., Sessions, Richard B., Edwards, Thomas A., Wilson, Andrew J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8179271/
https://www.ncbi.nlm.nih.gov/pubmed/34163995
http://dx.doi.org/10.1039/d0sc05694d

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8179271/
https://www.ncbi.nlm.nih.gov/pubmed/34163995
http://dx.doi.org/10.1039/d0sc05694d

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